GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| ACC | trans | rs9810890 | 1 | rs73198891 | chr3:128553841 | OR5V1 | chr6:29323008-29324054:- | 0.68 | 8.83 | 6.4E-12 | Dental caries |
| ACC | trans | rs9810890 | 1 | rs73198892 | chr3:128559117 | OR5V1 | chr6:29323008-29324054:- | 0.68 | 8.83 | 6.4E-12 | Dental caries |
| BLCA | cis | rs7714584 | 1 | rs1000113 | chr5:150240076 | LOC134466 | chr5:150310000-150326146:- | 0.53 | 6.99 | 1.26E-11 | Crohn's disease |
| BLCA | cis | rs7655841 | 1 | rs10002332 | chr4:129875301 | C4orf33 | chr4:130014829-130033842:+ | 0.28 | 4.37 | 1.61E-5 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs1109501 | 1 | rs10003641 | chr4:71340427 | AMTN | chr4:71384298-71398459:+ | 0.25 | 4.13 | 4.46E-5 | Alcoholism (heaviness of drinking) |
| BLCA | cis | rs2273 | 1 | rs10008757 | chr4:76903036 | NAAA | chr4:76831809-76862166:- | -0.39 | -6.41 | 4.28E-10 | Longevity |
| BLCA | cis | rs1109501 | 1 | rs10011835 | chr4:71340722 | AMTN | chr4:71384298-71398459:+ | 0.25 | 4.13 | 4.46E-5 | Alcoholism (heaviness of drinking) |
| BLCA | cis | rs11723261 | 1 | rs10021364 | chr4:310691 | ZNF718 | chr4:53272-156488:+ | -0.33 | -4.4 | 1.4E-5 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs1003719 | 1 | rs1003719 | chr21:38491095 | PIGP | chr21:38437664-38445458:- | -0.31 | -5.45 | 8.92E-8 | Eye color traits |
| BLCA | cis | rs1003719 | 1 | rs1003719 | chr21:38491095 | TTC3 | chr21:38445571-38575406:+ | 0.25 | 5.11 | 5.06E-7 | Eye color traits |
| BLCA | cis | rs7714584 | 1 | rs10041072 | chr5:150259642 | LOC134466 | chr5:150310000-150326146:- | 0.45 | 6.15 | 1.93E-9 | Crohn's disease |
| BLCA | cis | rs10461617 | 1 | rs10051747 | chr5:56083289 | C5orf35 | chr5:56205103-56213010:+ | 0.72 | 10.92 | 2.45E-24 | Type 2 diabetes |
| BLCA | cis | rs7714584 | 1 | rs10051804 | chr5:150226424 | LOC134466 | chr5:150310000-150326146:- | 0.4 | 4.98 | 9.62E-7 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs10051924 | chr5:150226639 | LOC134466 | chr5:150310000-150326146:- | 0.4 | 4.98 | 9.62E-7 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs10052606 | chr5:150272217 | LOC134466 | chr5:150310000-150326146:- | 0.46 | 5.97 | 5.47E-9 | Crohn's disease |